Case Study: Man with raised testosterone from using Activate Xtreme

With so many products purporting to elevate testosterone (we covered many in our review on testosterone boosting supplements), a common refrain from individuals is that these products lack any supporting evidence for their marketing claims. Supplement manufacturers will commonly retort that often evidence of effect can lead to regulation and increased costs making the testing of formulations (as opposed to individual compounds) prohibitive.

As a consequence of this most testosterone boosters have not been tested clinically, only the individual compounds included in the formulas having been researched in most cases. A recent clinical case (1) changes this though.

A 19 year old male which a history of low libido, and what he categorised as fluid retention submitted himself to his GP and said he was taking Driven Sports’ testosterone booster, Activate Xtreme. It is important to note this was the old version of this supplement which has since been reformulated, a point we will touch on later.


Driven Driven Sports Activate Xtreme


The doctors were unaware of this supplement so ran a blood test on the man which showed his testosterone levels were massively elevated as were his levels of luteinizing hormone, the hormone that triggers males to release more testosterone. The doctors tested for the presence of steroids of which there were none, Activate Xtreme being a testosterone booster not a steroid.

The values below show his testosterone levels when taking Activate Xtreme. As we can see testosterone at 41 nmol/L was far above even the highest end of the reference range for normal testosterone levels. If we assume an average testosterone level of around 16.5 nmol/L his testosterone levels would have more than doubled.


Activate Xtreme testosterone levels


After discontinuing the use of the Activate Xtreme his levels dropped back to 16.5nmol/L (the basis of our estimate for the increase above).


Activate Xtreme increases testosterone


Our Comments

On the face of it this shows that the old Activate Xtreme was a notable booster of testosterone but also estradiol which may account for the fact this individual also failed to report the positive effects associated with high testosterone levels. The fatter the individual, the greater the propensity for excess testosterone to convert to estrogen so this case study shows that keeping body fat levels down is a good idea to avoid a potential side effect of elevated estrogen.

This version included the same core ingredient found in the current Activate Xtreme, a compound called Divanil. Divanil can bind to sex hormone binding globule which then allows for free testosterone levels to increase. This formula also included some ingredients no longer included in the current Activate Xtreme which has replaced them with nutrients designed to stop the conversion of testosterone to estrogen such as an extract of brassaiopsis glumerulata, which acts as an aromatase inhibitor, as well as compounds shown to elevate growth hormone.

Real world reports suggested that some users of the old Activate Xtreme experienced symptoms associated with estrogen levels rising such as an initial increase in libido followed by an ensuing drop in libido. Since Activate Xtreme was reformulated to counteract the potential for an estrogenic rise, feedback as well as bloodwork conducted by Driven Sports on this supplement suggests that the product now will elevate testosterone but without the problematic rise in estrogen since the inclusion of an aromatase inhibitor specifically included to drive estrogen down.


Author: Reggie Johal


Recommended Reading

Activate Xtreme – Natural Testosterone Booster


Buy Activate Xtreme



1. McDonald TJ, Perry MH, Jones AG, Donohoe M, Salzmann MB, O’Connor J – Clinical Chemistry, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

© 2012, Reggie Johal. All rights reserved.

About Reggie Johal

Reggie Johal is a former Great Britain American Football player and the founder of Predator Nutrition. He has a strong background in strength and fitness coaching with articles published in Flex and other leading online and print magazines.

3 thoughts on “Case Study: Man with raised testosterone from using Activate Xtreme

  1. Interesting article Reggie. I have a couple of Q’s because I am really skeptical about these natural test boosters and their efficacy. I hear many people talking about increase in Testo and how beneficial this is, but I have not seen any real evidence that such an increase can produce substantial effects. Do you have any evidence (ie studies from peer reviewed journals) that a 2.5-fold increase in Testosterone can result in significantly changed ‘real-world’ parameters like muscle mass, strength, body composition etc?

    ”On the face of it this shows that the old Activate Xtreme was a notable booster of testosterone but also estradiol which may account for the fact this individual also failed to report the positive effects associated with high testosterone levels”

    The positive effects of high testo levels are noticed only when testo is raised to supraphysiological levels (please correct me if I m wrong). To the best of my knowledge a 2.5-fold increase from 16 to 41 nM is not supraphysiological.

    Forgive me but I have not access to the whole article, just the abstract. Can you please give me some info about the subject’s bodyweight, %BF and any other data they present?

    Furthermore, according to your statement, high estradiol levels can ‘blanket’ the positive testo effects; how do we know that Activate Xtreme is not responsible for this increase in estrogen?

    ”The fatter the individual, the greater the propensity for excess testosterone to convert to estrogen”. I do not quite understand this. In fat individuals the excess testosterone will convert into estrogen, whereas in lean individuals what will it convert into?

    Thank you in advance, Chris.

  2. i wonder why estrogen and testosterone are not measured in the same units.The range for e always seems extensive and its difficult to judge the ratio of e to test.or vice versa Do we know how many nmol/l =pmol/l ?

    i note as well that along with the rise in test , there is a rise in estrogen (oestradiol) and shbg .Its unfortunate that there is no free test measured , as judging by the rises in the former , some is being converted to e via the aromatise enzyme and more test is being bound through shbg

    just my thoughts on the above

  3. Chris – If we look at normal men without use of supplements enhanced levels of testosterone are indeed associated with greater muscle mass so taking levels beyond the normal physiological level could be expected to have a positive effect on mass and strength. In terms of real world studies they are not really something you tend to see studied at in universities unfortunately, nor is athletic enhancement of any kind looked upon kindly in healthy subjects where improvement could come via hormonal mechanisms.

    In terms of testosterone converting to estrogen in fatter men it is due to aromatase enzyme activity. In leaner men with lower levels of at (and aromatase) the tesosterone would not be converted into estrogen anything like to the same extent.

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